Young SD, Whissell M, Noble JC, Cano PO, Lopez PG, Germond CJ. Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia. Shanafelt TD, Lin T, Geyer SM, Zent CS, Leung N, Kabat B, et al. Msph LAT, Bray F, Siegel RL, Jacques Ferlay ME, Lortet-Tieulent J, Dvm AJ. This study provides useful information for its further application as an immune-stimulator in foods and drugs.Īuricularia auricula gut microbiota immune-stimulatory activity polysaccharides short-chain fatty acid.Ĭopyright © 2020 Kong, Duan, Li, Tang and Duan. Compared to the CTX group, AAP1 administration restored the gut microbiota composition similar to that of the control group by decreasing the ratio of Firmicutes/Bacteroidetes and increasing the relative abundances of short-chain fatty acid-producing microbiota. Results showed that AAP1 significantly enhanced immune organ indexes, remarkably stimulated IFN-γ, IL-2, IL-4, IL-10, and TNF-α levels in the serum, and dramatically up-regulated the mRNA levels of Claudin-1, Occludin and ZO-1. Secondly, the immune-stimulatory activities of the first AAP fraction (AAP1) were evaluated in the CTX-treated mice. Firstly, polysaccharides were isolated from A. This study aimed to evaluate the immuno-enhancing effects of AAP and mine its possible mechanisms. However, the immune-stimulatory activity and mechanisms of AAP in immunosuppressive mice treated with cyclophosphamide (CTX) are still poorly understood.
Recently, the immuno-enhancing potential of polysaccharide from Auricularia auricula (AAP) has been an area of research interest.
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